Novel substituted N - piridinil cyclic amides as Kinase Inhibitors

摘要

Refers to a compound of formula (a), and salts, enantiomers, rotamers, tautomeros racematos, or the pharmaceutically acceptable.Where q is c, N; RQ is h; r1 is H, c1-c4 alkyl, among others, r1b, r1c, R1D are each independently h, Halo, among others; 2a and R2B Selects CN, Halo, azido, among others; The pyridinyl ring to select from, pirimidinilo, among others.Also provided are methods of treating a disease or condition mediated by kinase PIM using compounds of formula I, and Pharmaceutical compositions comprising such compounds as the compound N - (4 - ((1R, 3R, 4R, 5S) - 5 - methyl - 3 - amino - 4 - (methylsulfonyl) cyclohexyl) pyridin-3-yl) - 6 - ( 2,6-difluoro-4 - (Tetrahydro - 2H - piran - 4-yl) oxy) phenyl) - 5 - fluoropicolinamida.