A thermodynamically Stable form of sorafenib tosylate Salt

摘要

Referred to a thermodynamically Stable compound at room temperature, the tosylate Salt of 4 - (4 - [({[4-chloro-3 - (trifluoromethyl) phenyl] amino] carbonyl] amino} - phenoxy) - 2 - (N - metilpiridin carboxamide. The Compound shown in the x-ray diffractometry The Peak Angle 2 Theta 4.4 11.4, 10.7, 11.1, among others.It also relates to a Pharmaceutical composition that is useful in the treatment of rheumatoid arthritis, retinopathy, among others.