Studies on Preformulation Characteristics and Production of Polymeric Nanoparticles of Sorafenib Tosylate

摘要

Sorafenib tosylate is a kinase inhibitor approved for both hepatic carcinoma and renal cellular carcinoma.It has drawback of poor solubility and so less cellular uptake.As the nanoparticles are promising to enhance solubility, cellular uptake, the present work aimd at preparation of nanoparticles of Sorafenib tosylate.Preformulation characteristics including interaction studies were carried out.Trial formulations containing different ratios of drug to polymer as 1?1, 1?1.5, 1:2, 1:2.5, 1:3, 1:3.5 were prepared by nanoprecipitation method using pectin as a polymer.Three formulations made with drug to polymer ratio of 1:2.5, 1:3 and 1:3.5.were produced successfully with mean particle size in nano range of 270.8nm 49.1nm, and 149.3 nm and respectively.