Pirazolil - 1 - 3 - (4 - ((2 - anilinopirimidin - 4-yl) oxy) naftalen - 1 - il) ureas as inhibitors of p38 Mitogen Activated Protein Kinases

摘要

On the compound 1 - (3 - tert - butyl - 1 - P - tolyl - 1H pyrazole - 5 - yl) - 3 - (4 - (2 - (phenylamino) - 4 - iloxi naftalen pyrimidin-2-yl) - 1 - il) urea of formula (i), as the Free Base in anhydrous Crystalline form It presents a pattern of Peaks in x-ray Powder diffraction selected 10.3, 15.2, 17.5, 23.1, 24.6, 26.7 27.4 degrees and 2 Theta. It also relates to a Pharmaceutical composition.This Compound is an inhibitor of the Enzyme Family of Protein Kinases Activated by p38 Mitogen and is useful in the treatment of inflammatory diseases, including inflammatory Lung diseases such as Asthma and COPD