THERAPEUTIC TREATMENT OF ACUTE T ​​lymphoblastic leukemias and lymphomas BY HUMAN BY receptor inhibition Interleukin-7 (IL-7R)

摘要

The present invention relates to the therapeutic treatment of human acute lymphoblastic leukemias (ALL) of T and B cells (T-and B-ALL) and human lymphomas, by inhibiting interleukin-7 receptor (IL-7R) human. A first aspect of the present invention is an inhibitor or blocker, preferably an antibody or a fragment thereof, capable of blocking the function of {the} chain receptor interleukin 7 (IL-7R {the}) human, for prevention and / or treatment of a human LLA or human lymphoma. Also, the present invention relates to a pharmaceutical composition and a model identification, expansion and maintenance in vivo primary initiating cells T-ALL and B-ALL human ability to initiate grafting leukemia in immunodeficient mice and characterization of these initiating cells T-ALL and B-ALL as cells expressing high levels of IL-7R.