porcine circovirus, nucleic acids, polypeptides and vaccines

摘要

Expression vector comprising a nucleotide sequence of a responsible porcine circovirus type II (PCV II) the post-weaning generalized weakness (PMWS) syndrome, wherein said nucleotide sequence of the vector comprises an open reading frame (MAL ) of porcine circovirus type II (PCV II), selected from said open reading frame of the group consisting of: - open reading frame 4 (MAL 4) consisting of nucleotides 398-1342 of the strand upstream of the sequence reference SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 6, - the open reading frame 13 (MAL 13) consisting of nucleotides 314-1377 of the antisense strand of the reference sequence SEQ ID NO: 1 or SEQ ID NO: 2 or nucleotides 314-1381 of the antisense strand of the reference sequence SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 6, - the open reading frame 7 (MAL 7) consisting of nucleotides 10 18-704 of the antisense strand of the reference sequence SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 6, and - the open reading frame 10 (MAL 10) consists of nucleotides 912 to 733 of the antisense strand of the reference sequence SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 6, said vector expressing expression in vitro or in vivo said open reading frame of porcine circovirus type II.