Procedure for selective binding of a substrate to sorbents by at least bivalent binding

摘要

Method for the selective bivalent bonding of a synthetic or natural substrate with at least two distinct groups capable of binding with a sorbent, comprising a solid carrier and at least two different groups capable of bonding with the synthetic or natural substrate, wherein the The method comprises steps (i) to (iv): (i) calculation of at least two groups capable of binding with a synthetic or natural substrate sorbent, (ia) bonding of a non-derivatized polymer through non-covalent interactions with the vehicle, (ii) introduction in each case of at least two different groups capable of binding with the synthetic or natural substrate through at least two identical or different functional groups of the polymer in this polymer, with the formation of at least one sorbent, where in the case of the groups it is groups that are complementary to the groups calculated in step (i), where a derivatized polymer with at least d The different groups capable of binding and in each case the at least two different groups capable of binding are covalently bound in the polymer, where (a) the groups are calculated in such a way that the contributions of the Gibbs energies of each of groups for non-covalent bonding with the substrate give a negative value of Gibbs ΔG energy, such that a potentiation of the bond occurs which results in an improved α separation selectivity of more than 1.4, with the that the substrate is separated by selectively binding with the at least two different groups capable of binding with the at least one sorbent using the at least one sorbent of the substrate mixture and where (iii) the contacting of the substrate with the sorbent of step (ii); (iv) testing the potency of the substrate bond with the sorbent of step (iii).