The invention provides a method of identifying a presence of Brugada Syndrome in a subject. In exemplary embodiments, the method comprises the steps of (i) analyzing a biological sample obtained from the subject for (a) a level of full-length messenger RNA (mRNA) encoded by the SCN5A gene, (b) a level of mRNA of an SCN5A splice variant which encodes a truncated SCN5A protein, (c) a level of mRNA encoded by a SCN5A splicing factor gene, and/or (d) a level of mRNA encoded by a gene of the unfolded protein response (UPR); and (ii) identifying the presence of Brugada Syndrome in the subject, when the level of (a), (b), and/or (d) are reduced, relative to a control level, and/or when the level of (c) is increased, relative to a control level.
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