NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT

摘要

A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R₁ is H, methyl, or benzyl: R₂ is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if X = S, R₂ = 0; Y is C₃ or C₄; Z₁ is O, S, N, or CH₂; and Z₂ is N or CR₄, wherein R₄ is a halogen, alkyl, aryl or a 5- or 6-membered heterocycle; and wherein said compound is selective for DOT1L Methyl Transferase.