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Genetic marker for the diagnosis of dementia with lewy bodies
Genetic marker for the diagnosis of dementia with lewy bodies
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机译:诊断路易体痴呆的遗传标记
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摘要
Specific alterations in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB), and allow distinguishing it from Alzheimer's disease. The invention provides an in vitro method for the diagnosis of DLB comprising determining in a biological sample from a subject, the genotype of the following alterations in butyrylcholinesterase (BChE) gene: the polymorphic sites at position 68974 in NCBI Accession Number NG_009031 (i.e. position 934 in SEQ ID NO: 28), and the polymorphic sites 3687, 4206, 4443, and the poly-thymine region at positions 4780 to 4786, said positions with reference to NCBI Accession Number NG_009031 (i.e. positions 3687, 4206 and 4443 respectively in SEQ ID NO: 1 ), which corresponds to the nucleotide sequence of human BChE gene.
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机译:已经发现BChE基因的特定改变,其可以确定患者是否患有路易体(DLB)痴呆,并且可以将其与阿尔茨海默氏病区分开。本发明提供了用于诊断DLB的体外方法,其包括在来自受试者的生物样品中确定丁酰胆碱酯酶(BChE)基因中以下改变的基因型:NCBI登录号NG_009031中的第68974位(即934位)的多态性位点。 SEQ ID NO:28中的多态性位点3687、4206、4443和多胸腺嘧啶区域在位置4780至4786,所述位置参考NCBI登录号NG_009031(即分别在SEQ ID NO:28中的位置3687、4206和4443) ID NO:1),其对应于人BChE基因的核苷酸序列。
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