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GENETIC MARKER FOR THE DIAGNOSIS OF DEMENTIA WITH LEWY BODIES
GENETIC MARKER FOR THE DIAGNOSIS OF DEMENTIA WITH LEWY BODIES
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机译:体征性痴呆的遗传标记
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摘要
Specific polymorphisms in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB) and allow distinguishing it from Alzheimer s disease. The invention provides an in vitro method for the diagnosis of DLB comprising determining in a biological sample from a subject the genotype of the following polymorphisms in butyrylcholinesterase (BChE) gene: the polymorphic site at position 3687 in NCBI Accession Number NG_009031 (i.e. SEQ ID NO: 1 ) the polymorphic site at position 4206 in SEQ ID NO: 1 the polymorphic site at position 4443 in SEQ ID NO: 1. and the polymorphic site at position 68974 in NCBI Accession Number NG_009031 (i.e. position 934 in SEQ ID NO: 26).
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机译:已经发现了BChE基因中的特定多态性,其可以确定患者是否患有路易体痴呆症(DLB),并且可以将其与阿尔茨海默氏病区分开。本发明提供了用于诊断DLB的体外方法,其包括在来自受试者的生物样品中确定丁酰胆碱酯酶(BChE)基因中以下多态性的基因型:NCBI登录号NG_009031中3687位的多态性位点(即SEQ ID NO: :1)SEQ ID NO:1中4206位的多态性位点,SEQ ID NO:1中4443位的多态性位点,以及NCBI登录号NG_009031中68974位的多态性位点(即SEQ ID NO:26中的934位) )。
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