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Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases
Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases
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机译:靶向VEGF-B调节脂肪酸转运蛋白以调节人类疾病
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摘要
The present invention provides materials and methods for modulating FATP expression and/or activity in vivo. In particular, the present invention concerns an oligonucleotide which inhibits VEGF-B expression for use in the treatment or prophylaxis of type II diabetes or metabolic syndrome wherein the oligonucleotide is selected from (a) an antisense oligonucleotide that inhibits VEGF-B transcription or translation or an expression vector which expresses such an oligonucleotide; or (b) a dsRNA that affects RNA interference or expresses such a dsRNA.
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