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ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING
ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING
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机译:乙酰胆碱结合蛋白配体,协同纳赫调节剂及制备和使用方法
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摘要
The invention provides compositions and methods a) for increasing or stimulating the release of other transmitters (excitatory amino acids, inhibitor amino acids and biogenic amines) in the central nervous system (CNS) or the brain, or modulating, decreasing or increasing the activity of an AChR in the CNS or brain, b) for treating, ameliorating, preventing or lessening the symptoms of an addiction or substance abuse involving modulating, decreasing or increasing levels or activity of dopamine in the CNS or brain, c) for treating, ameliorating, preventing or lessening the symptoms of an addiction or substance abuse involving e.g., drugs, narcotics or tobacco use, and d) for treating, ameliorating, preventing or lessening the symptoms of a disease or condition i.e., dementia, Parkinson's disease, pain or chronic pain, an allodynia, autism, psychosis or schizophrenia, responsive to the modulation of, or a decrease or an increase in the activity of nAChR.
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