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Acetylcholine binding protein, and methods of identifying agents that modulate acetylcholine receptor activity
Acetylcholine binding protein, and methods of identifying agents that modulate acetylcholine receptor activity
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机译:乙酰胆碱结合蛋白以及鉴定可调节乙酰胆碱受体活性的试剂的方法
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摘要
Fluorescence based screening assays are provided that allow for the for identification of agents that selectively bind to a ligand-gated ion channel (LGIC) such as a nicotinic acetylcholine receptor (nAChR). Also provided are methods for identifying agents that selectively bind to a neuronal-type nAChR by detecting binding of the agent to an Aplysia AChBP, which is representative of a neuronal-type nAChR. In addition, compositions and kits for performing such methods are provided.
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