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Complex formulation comprising hyperlipidemia treatment and omega-3 fatty acid

机译:包含高脂血症治疗和omega-3脂肪酸的复杂配方

摘要

The present invention relates to a composite formulation containing cholesterol and omega-3 fatty acids therapeutics as, [PEO-PPO-PEO] was added to form the triblock copolymers to screen a therapeutic agent for hyperlipidemia, which is soluble in the micelle glycol solvent as the hydrophobic group of the triblock copolymer, and the omega-3 fatty acids and a hydrophilic part makes a contact, it is not released after a delay long-term storage, excellent stability and can enhance the bioavailability of the drug, and, not easy to formulate a separate coating process to prevent contact of the omega-3 fatty acids and hyperlipidemia treatment Since increased levels of serum high-density lipoprotein, may be useful in the treatment of reducing the low density lipoprotein cholesterol and triglyceride levels. ;
机译:本发明涉及一种包含胆固醇和omega-3脂肪酸治疗剂的复合制剂,因为添加了[PEO-PPO-PEO]以形成三嵌段共聚物以筛选高脂血症的治疗剂,该治疗剂可溶于胶束二醇溶剂中。三嵌段共聚物的疏水基团与omega-3脂肪酸和亲水性部分接触,延迟长期保存后不释放,稳定性极好,可以提高药物的生物利用度,并且不易配制单独的包衣过程以防止omega-3脂肪酸接触和高脂血症的治疗由于血清高密度脂蛋白水平的升高,可能有助于降低低密度脂蛋白胆固醇和甘油三酸酯的水平。 ;

著录项

  • 公开/公告号KR1015198870000B1

    专利类型

  • 公开/公告日2015-05-14

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR1020130113386

  • 发明设计人 조선행;손여원;신병철;성하수;

    申请日2013-09-24

  • 分类号A61K31/20;A61K47/30;A61K47/48;A61P3/00;A61P3/06;

  • 国家 KR

  • 入库时间 2022-08-21 14:58:13

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