METHOD FOR PREPARING (S)-PREGABALIN PRECURSOR BY CATALYTIC ENANTIOSELECTIVE MICAHEL REACTION AND METHOD FOR PREPARING (S)-PREGABALIN USING THE (S)-PREGABALIN PRECURSOR

摘要

According to the present invention, a method for preparing chiral (S)-pregabalin precursors includes a step of enabling an asymmetric Michael reaction of beta-isobutyl nitro alkyne and malonate in the presence of a difunctional chiral catalyst. Accordingly, the present invention can synthesize chiral (S)-pregabalin precursors with high optical selectivity and reactivity under conditions of being harmless to a human body and not causing environmental pollution at low costs by using a catalyst safe to use.