New process for preparing benazepril precursor

摘要

The present work relates to a new synthesis process for the preparation of 3-[(1-ethoxycarbonyl-3-phenylpropyl)-amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate tert butyl ester(EPTAB),the precursor of benazepril HCl.The reaction conditions were optimized.The diastereomeric products were separated by flash column chromatography.The structures of the products were characterized with IR and NMR.