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METHOD FOR PREPARING PREGABALIN INTERMEDIATE, 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID, USING SOLVENT-FREE REACTION
METHOD FOR PREPARING PREGABALIN INTERMEDIATE, 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID, USING SOLVENT-FREE REACTION
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机译:无溶剂反应制备普拉格林中间体3-氨基氨基甲酸酯基-5-甲基己酸的方法
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摘要
The present invention provides a method for preparing a pregabalin intermediate3-carbamoymethyl-5-methylhexanoic acid without solvent. The method comprises the following steps: a) cooling an ammonia water system to a certain temperature; b) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; c) after completing the reaction, adding an acid to the system to adjust PH; d) after adjusting PH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and e) adding a solvent to the dried substance, slurrying, and suction filtering and drying to obtain the final product. The method provided in the present invention for preparing 3-carbamoymethyl-5-methylhexanoic acid is high-yield, green, environmentally-friendly, simple and convenient, and of less pollution.
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