REDUCING REGULATION OF TRANSCRIPTION Of SINE/Alu OF RETROTRANSPOZONES FOR INDUCTION OR RESTORING ABILITY the K OF PROLIFERATION AND/OR pluripotency OF STEM CELL

摘要

1. A method for inducing, restoring or maintaining the ability to proliferate and / or pluripotent mammalian cells, said method comprising: reducing or retrotransposon activity transcripts SINE / Alu in said cell in an amount sufficient to induce or restore the ability to proliferate and / or pluripotency mlekopitayuschego.2 said cell. A method according to claim 1, characterized in that said method comprises one or more of: restoration of the ability to proliferate and / or pluripotent mammalian cells, characterized by reduced or lost the ability to proliferate and / or reduced or lost pluripotency; induction capacity to proliferate and / pluripotency or mammalian cell which has no such ability, the ability to maintain the proliferation and / or cell pluripotency mlekopitayuschego.3. A method according to claim 1, characterized in that said mammalian cell comprises a cell selected from the group consisting of a stem cell, non-renewable precursor cells, terminally differentiated cells and aging kletki.4. A method according to claim 3, characterized in that said mammalian cell comprises a stem cell selected from the group consisting of embryonic stem stand, cord blood stem cells, adult stem cells and induced pluripotent stem cells (iPSC) .5. A method according to claim 3, characterized in that said stem cell is a mammalian stem cell derived from a tissue selected from the group consisting of human fat tissue, bone