1. An autoinjector (1) for administering a dose of a liquid medicine (M), comprising: a tubular frame (2) configured to comprise a syringe (3) with a hollow needle (4) and a plug (6) for sealing the syringe (3) and the movement of the drug (M), and the frame (2) has a distal end (D) and a proximal end (P) with a hole designed to be applied close to the injection site, where the syringe (3) is made with the possibility of sliding relative to the frame (2), a drive spring (8) capable of driving a syringe (3) to deliver a dose of lek an artificial agent (M), an adjustment spring (19) capable of pushing the needle (4) from the closed position inside the frame (2) to the extended position through the hole and behind the proximal end (P) to insert the needle, and push the frame (2) over the needle (4 ) after at least partial delivery of the drug (M), the actuation means configured to lock the drive spring (8) and the control spring (19) in a compressed state until operating in manual mode and with a function when operating in manual mode regulatory release mode th spring (19) and / or a drive spring (8) for injection, where the holder subassembly containing the tubular holder (7) is slidably mounted in the frame, the holder (7) comprising a syringe (3), a drive spring (8) and a plunger (9) for transferring the load of the drive spring to the plug (6), where the syringe (3) is blocked for joint longitudinal movement with the holder (7), where the control spring (19) is made with the possibility of connection with the holder (7) by means of the first locking means (20 , 23, 24) for introducing the needle, and means for actuating with
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