METHOD FOR INHIBITING HAMARTOMA TUMOR CELL CELLS

摘要

1. A method of inhibiting the growth or proliferation of hamartoma tumor cells, comprising administering to a patient in need thereof, in an amount that is effective to inhibit the growth or proliferation of hamartoma tumor cells, a compound of the formula wherein R is hydrogen or halogen; R 1 is hydrogen, cyano, nitro, halogen, hydroxyl, amino or trifluoromethyl; R 1 is hydrogen or halogen; R is hydrogen, methyl or ethyl, and W is CR or N, where R is hydrogen, cyano, halogen, methyl, trifluoromethyl or sulfonamido; or a pharmaceutically acceptable salt thereof. 2. The method according to claim 1, where W represents CH.3. The method according to claim 1, where R represents hydrogen; R 1 is hydrogen or trifluoromethyl; R represents hydrogen and R represents hydrogen. 4. The method according to claim 3, where W represents CH.5. The method according to claim 4, where R is trifluoromethyl. The method of claim 1, wherein the compound of formula (I) is 4- (trifluoromethyl) -5- (2,6-dimorpholinopyrimidin-4-yl) pyridin-2-amine or a pharmaceutically acceptable salt thereof. The method according to claim 1, wherein the amount of a compound or salt of formula (I) that is effective for inhibiting the growth or proliferation of hamartoma tumor cells is from 0.001 to 1000 mg / kg. The method according to claim 6, wherein the amount of a compound or salt of formula (I) that is effective for inhibiting the growth or proliferation of hamartoma tumor cells is from 1.0 to 1000 mg / kg. A method for treating PTEN tumor syndrome of hamartoma, comprising administering to a patient in need thereof, in an amount that is effective for inhibiting the growth or proliferation of tumor cells of hamar