SULPHONAMIDE COMPOUNDS WITH ANTAGONISTIC ACTIVITY AGAINST TRPM8

摘要

1. The compound of General formula (I): in which ring A is a bicyclic aromatic heterocycle consisting of (a) pyridine condensed with benzene; or (b) pyridine condensed with a monocyclic aromatic heterocycle, and ring A is bonded to a sulfonylamino group on a carbon atom adjacent to the nitrogen atom of the pyridine ring included in ring A; ring B is (a) a monocyclic or bicyclic aromatic hydrocarbon; (b) a monocyclic or bicyclic alicyclic hydrocarbon; (c) a monocyclic or bicyclic aromatic heterocycle; or (d) a monocyclic or bicyclic non-aromatic heterocycle, ring C is (a) benzene; or (b) a monocyclic aromatic heterocycle, R is (a) hydrogen; (b) optionally substituted alkyl; (c) optionally substituted cycloalkyl; (d) an optionally substituted alkoxy group; (e) optionally substituted phenyl; (f) halogen; or (g) nitrile, each of R, R, R and R independently represents (a) hydrogen; (b) optionally substituted alkyl; (c) optionally substituted cycloalkyl; (d) an optionally substituted alkoxy group; (e) optionally substituted phenyl; (f) an optionally substituted monocyclic aromatic heterocyclic group; (g) an optionally substituted monocyclic non-aromatic heterocyclic group; (h) halogen; or (i) nitrile, each of R, R, R and R independently means (a) hydrogen; (b) optionally substituted alkyl; (c) optionally substituted cycloalkyl; (d) an optionally substituted alkoxy group; (e) an optionally substituted cycloalkoxy group; (f) optionally substituted �