首页> 外国专利> 4-amino-5-fluoro-3- 6- (4-methylpiperazin-1-yl) -1h-benzimidazole-2-yl -1h-quinolin-2-one for use in the treatment of adenocystic carcinoma

4-amino-5-fluoro-3- 6- (4-methylpiperazin-1-yl) -1h-benzimidazole-2-yl -1h-quinolin-2-one for use in the treatment of adenocystic carcinoma

机译:4-氨基-5-氟-3- [6-(4-甲基哌嗪-1-基)-1h-苯并咪唑-2-基] -1h-喹啉-2-酮用于治疗腺囊性癌

摘要

1. The use of 4-amino-5-fluoro-3- [6- (4-methylpiperazin-1-yl) -1H-benzimidazol-2-yl] -1H-quinolin-2-one or its tautomer or its pharmaceutically acceptable salt for the treatment of adenocystic carcinoma. 2. A method for reducing solid tumors or preventing the progression of solid tumors in a subject with adenocystic carcinoma, comprising administering a therapeutically effective amount of 4-amino-5-fluoro-3- [6- (4-methylpiperazin-1-yl) -1H-benzimidazol-2-yl ] -1H-quinolin-2-one or a pharmaceutically acceptable salt thereof in combination with docetaxel or a pharmaceutically acceptable salt thereof. 3. Use of 4-amino-5-fluoro-3- [6- (4-methylpiperazin-1-yl) -1H-benzimidazol-2-yl] -1H-quinolin-2-one or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier for for the preparation of a medicament for the treatment of solid tumors in a subject with adenocystic carcinoma. 4. Combination of 4-amino-5-fluoro-3- [6- (4-methylpiperazin-1-yl) -1H-benzimidazol-2-yl] -1H-quinolin-2-one or its tautomer or pharmaceutically acceptable salt and docetaxel for use in the treatment of adenocystic carcinoma. 5. A method for reducing solid tumors in a subject with adenocystic carcinoma, comprising administering a therapeutically effective amount of 4-amino-5-fluoro-3- [6- (4-methylpiperazin-1-yl) -1H-benzimidazol-2-yl] -1H-quinoline -2-one or a tautomer thereof or a pharmaceutically acceptable salt thereof in combination with docetaxel or a pharmaceutically acceptable salt thereof. 6. The use of the combination according to claim 4 for the manufacture of a medicament for the treatment or prevention of solid tumor growth in a patient with adenocystic carcinoma. 7. Use of 4-amino-5-fluoro-3- [6- (4-methylpiperazin-1-yl) -1H-benzimidazol-2-yl] -1H-quinolin-2-o
机译:1. 4-氨基-5-氟-3- [6-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基] -1H-喹啉-2-酮或其互变异构体或其药学上的用途可接受的盐用于治疗腺囊性癌。 2.一种在患有腺囊癌的受试者中减少实体瘤或预防实体瘤进展的方法,其包括施用治疗有效量的4-氨基-5-氟-3- [6-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基] -1H-喹啉-2-酮或其药学上可接受的盐与多西他赛或其药学上可接受的盐的组合。 3. 4-氨基-5-氟-3- [6-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基] -1H-喹啉-2-酮或其药学上可接受的盐的用途,和药学上可接受的载体,用于制备用于治疗患有腺囊癌的实体瘤的药物。 4. 4-氨基-5-氟-3- [6-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基] -1H-喹啉-2-酮或其互变异构体或可药用盐的组合和多西他赛用于治疗腺囊性癌。 5.一种用于减轻患有腺囊癌的受试者的实体瘤的方法,包括给予治疗有效量的4-氨基-5-氟-3- [6-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2 -基] -1H-喹啉-2-酮或其互变异构体或其可药用盐与多西他赛或其可药用盐组合。 6.根据权利要求4的组合在制备用于治疗或预防患有腺囊性癌的患者中实体瘤生长的药物中的用途。 7.使用4-氨基-5-氟-3- [6-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基] -1H-喹啉-2-o

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