METHOD coulometric determination of water content of the dosage form OINTMENT

摘要

A method for determining the water content in the dosage form of ointment by coulometric titration, characterized in that it is based on the interaction of water contained in the test sample to coulometric titrant - electrogenerated iodine that is generated by the electrolysis of an organic or inorganic iodide (e.g. CHI or KI), the incoming of the supporting electrolyte at a constant current of 50 mA, the water content (X, g) aliquot of the test sample is calculated as follows: X = I × t × M / Fgde I - current, 0,05 A; t - time to reach the titration end point s; M - molar mass equivalents of water, 9.008 g / mol; F - Faraday constant 96485 C / mol, parallel determination of water is carried out in a solvent and well-known formulas calculate the content of water in the ointment.