METHOD FOR STIMULATING RESTORATION OF TISSUE INNERVATION FOLLOWING INJURIES AND ISCHEMIA BY MEANS OF VECTOR CONSTRUCT

摘要

FIELD: medicine.;SUBSTANCE: therapeutically effective amount of a recombinant plasmid with a nucleotide sequence of SEQ ID NO:1, which contains a modified nucleotide sequence coding human BDNF, and the Kozak consensus sequence, is introduced into an involved muscle; pVax1 Invitrogen is used as a plasmid vector.;EFFECT: invention discloses an effective method to accelerate the restoration of the structure and conductivity of peripheral nerves after an injury, by transfection of the muscles innervated by the injured nerve, by means of a new plasmid construct coding the brain-derived neurotrophic factor.;3 cl, 5 dwg, 4 ex