METHOD FOR CORRECTING BONE MICROCIRCULATION ACCOMPANYING EXPERIMENTALOSTEOPOROSIS AND UNDERLYING FRACTURES WITH USE OF COMBINATION OF L-ARGININE AND ENALAPRIL

摘要

FIELD: medicine.;SUBSTANCE: method involves simulating osteoporosis in female Wistar rats by a bilateral ovariectomy, and osteoporotic fractures, performing a pharmacological correction of pathological conditions by a combination of L-arginine 200mg/kg and enalapril 0.5mg/kg administered intragastrically daily, as a single dose once a day.;EFFECT: using the declared invention provides the synergetic action consisting in the positive effect on the bone microcirculation in osteoporosis and in an osteotylus in osteoporotic fractures.;1 ex