METHOD OF CORRECTING MICROCIRCULATION IN BONE TISSUE WITH COMBINATION OF L-NORVALIN AND ROSUVASTATIN IN CASE OF EXPERIMENTAL OSTEOPOROSIS AND FRACTURES AT ITS BACKGROUND

摘要

FIELD: medicine.;SUBSTANCE: invention relates to field of medicine and is intended for impact on microcirculation in bone tissue in case of experimental osteoporosis and fractures at its background. Method includes introduction of combination of pharmacological preparations to animal after modelling osteoporosis by means of bilateral ovariectomy and osteoporotic fractures of hip bone in female rats of Wistar line. As such preparations used is combination of L-norvalin in dose 10 mg/kg and rosuvastatin in dose 0.86 mg/kg, which is introduced to laboratory animal daily intragastrically one time per day at the background of osteoporosis modelling during eight weeks, and in case of fractures at the background of osteoporosis modelling during twelve weeks.;EFFECT: application of claimed invention results in synergism in positive impact on indices of microcirculation in bone tissue in case of osteoporosis and in bone callus in case of osteoporotic fractures.;1 ex