METHOD FOR CORRECTING BONE MICROCIRCULATION ACCOMPANYING OSTEOPOROSIS AND UNDERLYING FRACTURES WITH USE OF COMBINATION OF L-ARGININE AND LOSARTAN

摘要

FIELD: medicine.;SUBSTANCE: method involves administering a combination of pharmacological agents into a laboratory animal after simulating osteoporosis by a bilateral ovariectomy and osteoporotic femoral fracture in female Wistar rats. This agents represent a combination of L-arginine 200mg/kg and losartan 6mg/kg, which is intragastrically administered daily into a laboratory animal once a day with underlying stimulating osteoporosis for eight weeks, and in fractures- with underlying simulating osteoporosis for twelve weeks.;EFFECT: using the declared invention provides the synergetic action and positive effect on the bone microcirculation in osteoporosis and in an osteotylus in osteoporotic fractures.;1 ex