首页>
外国专利>
Methods and molecular pharmacodynamic biomarkers for a wide variety of signaling pathways in response to orotic acid carboxamidotriazole
Methods and molecular pharmacodynamic biomarkers for a wide variety of signaling pathways in response to orotic acid carboxamidotriazole
展开▼
机译:响应乳清酸羧酰胺基三唑的多种信号通路的方法和分子药效生物标志物
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides methods, pharmacodynamic biomarker signatures for a wide variety of signaling pathways in a subject cell sample (eg, growth hair) that respond to orotate carboxamidotriazole (CTO). In clinical trials, CTO has shown responses in several cancers with various genomic mutations. The present invention provides a diagnostic and prognostic assay that tracks the CTO response, which response is associated with several transcriptional signatures associated with tumor inhibition (EGFR, MEK, HDAC, RAS, GFS, WNT, HSP90 or non-potential dependent) Show differential expression ranging from -100 fold to +25 fold in calcium signaling (including calcium signaling), while tumor suppressor signatures (eg P53 or EGR1) are induced in the growth phase hair assay.
展开▼