MONOCLONAL ANTIBODIES AND FRAGMENT THEREOF AGAINST THE HUMAN ANTI-MULLERIAN HORMONE TYPE II RECEPTOR (AMHR-II)

摘要

PROBLEM TO BE SOLVED: To provide monoclonal antibodies and fragment thereof specific to the human anti-mullerian hormone type II receptor (AMHR-II) for use in the treatment and diagnosis of cancer diseases such as ovarian cancer.SOLUTION: The monoclonal antibodies having specificity to the human anti-mullerian hormone type II receptor (AMHR-II) comprising (a) a heavy chain where the variable domain comprises at least one CDR having a sequence selected from the group consisting of amino acid sequences of specific sequences for CDR-1, CDR-2, and CDR-3 and/or (b) a light chain where the variable domain comprises at least one CDR having a sequence selected from the group consisting of amino acid sequences of specific sequences for CDR-1, CDR-2, and CDR-3.SELECTED DRAWING: None