MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF DIRECTED AGAINST HUMAN ANTI-MULLERIAN HORMONE TYPE II RECEPTOR (AMHR-II)

摘要

PROBLEM TO BE SOLVED: To provide monoclonal antibodies and fragments thereof specific to human anti-mullerian hormone type II receptor (AMHR-II) for use in treatment and diagnosis of cancer diseases such as ovarian cancer.SOLUTION: There are provided monoclonal antibodies comprising (a) a heavy chain whose variable domain comprises at least one CDR having a sequence selected from the group consisting of respective specific sequences related to CDR-1, CDR-2 and CDR-3, and/or (b) a light chain whose variable domain comprises at least one CDR having a sequence selected from the group consisting of respective specific sequences related to CDR-1, CDR-2 and CDR-3, the monoclonal antibodies having specificity to human anti-mullerian hormone type II receptor (AMHR-II).