Synthetic antibody mimetic compounds (SyAM) targeting cancer, particularly prostate cancer

摘要

The present invention relates to compounds that function as antibody mimetic compounds. These compounds comprise at least one cancer cell binding moiety that selectively binds prostate specific membrane antigen (PSMA) and a FC receptor binding moiety that modulates an FC immune receptor, preferably an FcγRI receptor. It is a functional / polyfunctional compound. The compounds of the present invention selectively bind to cancer cells that upregulate PSMA, and through such interactions, the Fc receptor binding portion of the compound is located in close proximity to the Fc receptor, preferably the FcγRI receptor. Thus, it is possible to modulate (preferably up-regulate) the patient's fluid response to cancer cells. Through such biological action of the compounds of the present invention, cancer cells, including metastatic cancer cells, in particular prostate cancer cells, can be immunomodulated, resulting in preferred cancer treatment in patients. Methods of using such compounds to treat cancer and / or reduce the likelihood of cancer metastasis are a further aspect of the invention.