Antibody-Dendrimer Conjugates for Targeted Prostate Cancer Therapy

摘要

Targeted therapy is potentially an important means of attacking cancer.Better outcomes for hormone resistant tumors may be achieved by specifically delivering drugs,radionuclides or toxins to tumors to specifically kill tumor cells without affecting surrounding tissue.Targeted therapy is dependent on specific marker for the cancer cells that can be identified with affinity agents such as antibodies(for antigens)or ligands(for receptors).One of the targeting agents associated with the prostate is prostate specific membrane antigen(PSMA).Several anti-PSMA monoclonal antibodies(MoAbs)that bind the extracellular PSMA domain have been developed.Dendrimer Conjugates.