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Nanofibre and Bioactive Compositions and Related Methods

机译:纳米纤维和生物活性成分及相关方法

摘要

Described herein are compositions in nanofibre form including one or more bioactive compounds releasably incorporated thereon. In one embodiment a composition is described comprising at least one nanofibre and at least one bioactive compound. The nanofibres are formed from a base material that is solubilised with the bioactive or bioactives in an aqueous based solvent solution and the base material and bioactives are together spun via electrospinning to form dry fibres with the bioactives chemically bonded to the nanofibres and the bioactives remaining stable during storage of the composition under ambient conditions substantially free of moisture. On exposure to moisture, the nanofibres dissolve, thereby releasing the bioactives.
机译:本文描述的是纳米纤维形式的组合物,其包括可释放地并入其上的一种或多种生物活性化合物。在一个实施方案中,描述了一种包含至少一种纳米纤维和至少一种生物活性化合物的组合物。纳米纤维由被生物活性剂或生物活性剂溶解在水性溶剂溶液中的基础材料形成,并且该基础材料和生物活性剂通过电纺丝一起纺丝以形成干纤维,其中生物活性剂化学键合到纳米纤维上并且生物活性剂保持稳定在环境条件下将组合物储存期间基本上没有水分。暴露在湿气中,纳米纤维会溶解,从而释放出生物活性物质。

著录项

  • 公开/公告号US2016038611A1

    专利类型

  • 公开/公告日2016-02-11

    原文格式PDF

  • 申请/专利权人 ACTIVE FIBRES LIMITED;

    申请/专利号US201414774365

  • 申请日2014-03-12

  • 分类号A61K47/48;A61K8/02;A61K8/97;A61K8/65;A61K8/98;A61Q19/02;A61Q19;A61Q19/08;A61K36/87;A61K36/73;A61K36/185;A61K35/644;A61K9/70;B29C65/76;A61K8/66;

  • 国家 US

  • 入库时间 2022-08-21 14:38:23

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