A balloon catheter includes a drug-coated balloon having an uncoated region free from drug coating, a displaceable protective sleeve covering the drug-coated balloon and an elongate catheter body that has a distal end and a proximal end. Another catheter has an uncoated region and/or an additional uncoated balloon is on the catheter body. The uncoated balloon or the additional uncoated balloon are mounted to be exposed first when the sleeve is displaced. This blocks blood flow while the drug coated balloon or balloon region is inflated to avoid or minimize release of drug into the blood stream away from the site of treatment.
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