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NOVEL ESTERIFIED CELLULOSE ETHERS OF LOW VISCOSITY AND HIGH MOLECULAR WEIGHT

机译:低粘度和高分子量的新型酯化纤维素醚

摘要

Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up 19 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and which have a weight average molecular weight Mw of at least 90,000 Dalton, are useful for preparing solid dispersions comprising drugs.
机译:包含(i)脂族单价酰基或(ii)式-C(O)-R-COOA的基团的酯化纤维素醚,其中R为二价脂族或芳族烃基,A为氢或阳离子,或( iii)脂肪族一价酰基和式-C(O)-R-COOA的基团的组合,其粘度高达19 mPa·s,以酯化纤维素醚在丙酮中的10 wt%溶液测得20℃且具有至少90,000道尔顿的重均分子量M ,可用于制备包含药物的固体分散体。

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