Method to produce N-acyl amino acid surfactants using N-acyl amino acid surfactants or the corresponding anhydrides as catalysts

摘要

A process of producing N-acyl amino acid based surfactants of Formula I,; wherein, R is selected from C6 to C22 alkyl group, R₁ is selected from H, C1 to C4 alkyl, R₂ is selected from all groups on α carbon of natural amino acids, R₃ is selected from COOX, CH₂—SO₃X, X is selected from Li⁺, Na⁺ or K⁺. The process comprising steps of:A) preparing fatty acid chlorides by halogenating fatty acids with either phosgene or thionyl chloride in the presence of catalytic amount of same or other N-acyl amino acid surfactant of Formula I or anhydrides of same surfactant; andB) reacting fatty acid chloride of step (A) with an amino acid in the presence of a base.