A purified DOC1 polypeptide comprising a fragment of SEQ ID NO:1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting angiogenesis. A method of inhibiting tumor growth in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting tumor growth.
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机译：提供了包含SEQ ID NO：1的片段的纯化的DOC1多肽，其中所述DOC1多肽不是全长DOC1多肽序列。提供了一种抑制受试者中血管生成的方法，该方法包括向受试者施用编码DOC1多肽的核酸，由此受试者中的细胞产生DOC1多肽，从而抑制血管生成。提供了一种在受试者中抑制肿瘤生长的方法，该方法包括向受试者施用编码DOC1多肽的核酸，由此受试者中的细胞产生DOC1多肽，从而抑制肿瘤生长。
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