tetrapyrrolic compound and pharmaceutically acceptable pharmaceutical composition thereof and their uses and methods of photodynamic therapy and diagnosis and treatment of arthritis and similar inflammatory diseases.

摘要

tetrapyrrolic compound and pharmaceutically acceptable pharmaceutical composition thereof and their uses and methods of photodynamic therapy and diagnosis and treatment of arthritis and similar inflammatory diseases. The present invention provides methods for obtaining biologically active compounds which can be used as photosensitizers for diagnostic and therapeutic applications, in particular for cancer pdt, infections and other hyperproliferative diseases, diagnosis and treatment of fluorescence pdt of a non-tumor indication. such as arthritis, inflammatory diseases, viral diseases or bacterial infections, dermatological, ophthalmic or urological diseases. One embodiment of the present invention is a method for synthesizing dicheto chlorins as precursors. In yet another embodiment, these precursors are converted to functionalized Î ± -hydroxy and dihydroxy chlorins. another embodiment is to provide the amphiphilic compounds with higher membrane affinity and increased pdt efficacy. Another embodiment is the formulation of the desired isomer in a loposome formulation at the injection site or delayed pharmacokinetics of tetrapirrol systems.