'Use of genetically modified mice in the preparation of an antibody and method for producing antibodies.'

摘要

Patent Summary: "Non-human animals expressing antibodies having a common light chain". The present invention relates to a genetically modified mouse, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice that express only one or a few immunoglobulin light chain domains of a limited repertoire in their germline are provided. Methods for making light chain variable regions in mice, including human light chain variable regions are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, for example bispecific antibodies, are provided.