biosensor having interdigitated electrodes for nanomedicine application in detection and diagnosis

摘要

biosensor having interdigitated electrodes for nanomedicine application in detection and diagnosis. construction of a biosensor to detect specific anti-leishmania antibodies using an electrode containing gold interdigitated trails. On this surface, the proteoliposome containing a pool of antigenic proteins is immobilized by self - assembly in alternating layers with positive polyelectrolytes. The detection of these antibodies is performed by electrical impedance and resistance measurements, which can be related to analyte concentrations in a single coordinate axis, with capacitance or resistance versus concentration. This methodology allows obtaining a biosensor for anti-leishmania antibodies. In addition, with the use of proteoliposomes containing chagas disease antigens, the device disclosed in the present invention can also diagnose chagas disease without the risk of false positive as in leishmaniasis.