OPC2 PROVIDING OPC2 PCV2 AND CONTAINING ITS VIRUS-LIKE PARTICLES

摘要

The application describes vaccination methods for controlling infection with PCV2 using various PCV2 subtypes. In particular, the OPV2 proteins of PCV2 subtype b (PCV2b) or immunogenic compositions containing the OPC2 protein PCV2b are used in a method for treating or preventing infection with PCV2 of the same PCV2b subtype and / or another subtype; in a method of reducing, preventing, or treating clinical signs caused by an infection using PCV2 of the same PCV2b subtype and / or another subtype; and / or in a method of preventing or treating a disease caused by an infection using PCV2 of the same PCV2b subtype and / or another subtype. This application also describes the OPV2 proteins of the PCV2 subtype b (PCV2b), characterized in that they contain at least one mutation in the BC-loop, as a result of which the expressed protein is preferably expressed in a higher amount compared to the PCV2 ORC2 protein, which is not contains the indicated mutation.