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TARGETED THERAPY TO RESTORE RADIOACTIVE IODINE TRANSPORT IN THYROID CANCER
TARGETED THERAPY TO RESTORE RADIOACTIVE IODINE TRANSPORT IN THYROID CANCER
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机译:靶向治疗可恢复甲状腺癌中放射性碘的运输
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摘要
The invention includes method, pharmaceutical compositions and uses thereof for treating patients with Papillary Thyroid Carcinoma (PTC) using a Platelet Derived Growth Factor Receptor Alpha (PDGFRA) inhibitor. The PDGFRA inhibitor is preferably an antibody specific to PDGFRA and causes an increase in the sensitivity level of PTC cells to radioiodine treatment. Moreover, the antibody can be used in combination with other PDGFRA inhibitors such as tyrosine kinase inhibitors and RNA interference molecules.
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