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CYCLIC PHOSPHOPEPTIDE COMPOUNDS AS ALLOSTERIC PLK1-PBD INHIBITOR

机译:环磷肽化合物作为异位PLK1-PBD抑制剂

摘要

The present invention relates to a novel cyclic phosphopeptide compound having allosteric PLK1-PBD inhibitory activities. The compound of the present invention has PLK1-PBD inhibitory activities, and is useful as an antitumor agent. The present invention provides a cyclic phophopeptide compound represented by chemical formula 1, a hydrate thereof, a solvate thereof, an isomer thereof, or a racemic body and pharmaceutically acceptable salt thereof.
机译:本发明涉及具有变构PLK1-PBD抑制活性的新型环状磷酸肽化合物。本发明的化合物具有PLK1-PBD抑制活性,并且可用作抗肿瘤剂。本发明提供由化学式1表示的环状磷酸肽化合物,其水合物,其溶剂化物,其异构体或外消旋体及其药学上可接受的盐。

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