An aspect of the present invention includes a method of applying to a subject a transdermal delivery device configured to deliver a non-metastatic amount of a dexmedetomidine composition. In practicing the methods according to certain embodiments, the non-metastatic amount of dexmedetomidine composition is applied transdermally to the subject and is maintained in contact with the subject in a manner sufficient to deliver a non-dose of dexmedetomidine to the subject . A kit comprising a transdermal delivery device having a non-dose-dependent amount of dexmedetomidine sufficient to perform the method, and a transdermal delivery device is also provided.
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