4- 4- Mutants Having a High Producing Ability of 4-Hydroxybutyrate and Preparing Method for 4-Hydroxybutyrate Using the Same

摘要

Relates to a production method of the present invention are 4-hydroxy-butyric acid 4-hydroxy performance having mutant microorganisms and using them to suffer hydroxy butyric acid, 4-hydroxy butyric acid is in more detail the gene for synthesis of 4-hydroxy butyric acid and from succinic acid is amplified in order to increase the producing ability, the supplementary circuit (anaplerotic pathway) a gene which is amplified, competition genes having a 4-hydroxy-butyric acid which is hard performance deletion mutant microorganism and a method for manufacturing the same in US aerobic (micro-aerobic) conditions, high yields of the 4-hydroxy-butyric acid and cultured in. The present invention is useful for the manufacture of 4-hydroxy butyric acid producing ability by having a mutation to prepare a microorganism, using this, the high yields of 4-hydroxy-butyric acid. ;