4- 4- A microorganism producing 4-hydroxybutyrate and a method for producing 4-hydroxybutyrate in anaerobic condition using the same

摘要

One aspect attenuates maleate quinone oxidoreductase activity to a strain producing 4HB, attenuates phosphoenolpyruvate carboxykinase activity, or encodes alpha-ketoglutarate synthase or a variant thereof It is to improve the production capacity of 4HB by introducing polynucleotide or by introducing a polynucleotide encoding a variant of pyruvate carboxylase. In addition, the production capacity was further improved by introducing a polynucleotide encoding pyruvate dehydrogenase and formate dehydrogenase. The strain transformed as described above can produce 4HB with high yield through anaerobic fermentation, so such a strain can be very useful industrially.