A MICROORGANISM PRODUCING 4-HYDROXYBUTYRATE AND A METHOD FOR PRODUCING 4-HYDROXYBUTYRATE IN ANAEROBIC CONDITION USING THE SAME

摘要

The present invention relates to a strain that produces 4-hydroxybutyrate (4HB) wherein the activity of malate quinone oxidoreductase or phosphoenolpyruvate carboxykinase is reduced or removed; or introduces a polynucleotide that codes alpha-ketoglutarate synthase or mutants thereof, or pyruvate carboxykinase or mutants thereof, thereby improving the productivity of 4HB. Also, the strain has an additonally improved function of producing 4HB by introducing polynucleotide that codes pyruvate dehydrogenase and formate dehydrogenase. In the present invention, the transgenic strain in an anaerobic fermentation is used for producing 4HB in a high yield rate, thus being very useful in industrial application.