EpCAM Nucleic acid aptamer specifically binding to EpCAM and their uses

摘要

The present invention relates to a DNA aptamer exhibiting a high affinity specifically to EpCAM (epithelial cell adhesion molecule (EpCAM)) from a randomly synthesized ssDNA library using SELEX (Systematic Evolution of Ligands by Expectant Enrichment) The DNA aptamer that can specifically bind to EpCAM can be used to measure EpCAM more sensitively and accurately than antibody-based assays used in the past, and the DNA aptamer can be used as a marker of cancer stem cells or embryonic stem cells Stem cell or cancer research and diagnosis.