GPCR Ligand Peptides and a Conserved Motif Theirof

摘要

The present invention relates to a novel GPCR ligand peptide and a screening method for identifying the same. The present invention provides a GPCR ligand peptide represented by the following general formula 1:1 NH ₂ -Xa ₁ -Xa ₂ -Xa ₃ -Xa ₄ -Xa ₅ -Cys-His-Phe-Lys-Xa ₆ -Cys-Asn-Met-CONH ₂ In the general formula 1, Xa ₁ is Gln, Asn, His, Ser, Thr or Pro; Xa ₂ is Tyr or Arg; Xa ₃ is Met, Leu or Ile; Xa ₄ is Ser, Thr, Ala or Gln; Xa ₅ is Pro, Leu or Met; Xa ₆ is Ile or Leu. In addition, the screening method of the present invention can provide a signaling peptide ligand having the following characteristics: (i) a sequence having one transmembrane domain; (ii) the presence of a signal peptide sequence; And (iii) a sequence that does not have a functional domain.